Studies
A Phase 3 Trial of L-Glutamine in Sickle Cell Disease
This pivotal, randomized controlled trial demonstrated that oral therapy with pharmaceutical-grade L-Glutamine significantly reduces the frequency of pain crises and hospitalizations in patients with sickle cell disease. The study highlights L-Glutamine's role in mitigating oxidative stress on red blood cells, providing a strong scientific basis for its use in supporting cellular health and function.
Patterns of exercise-related inflammatory response in sickle cell trait carriers
This study investigated the effects of strenuous exercise on individuals with Sickle Cell Trait (SCT), finding that intense physical activity triggers a unique inflammatory and cellular response compared to those with normal hemoglobin. These findings underscore the specific physiological demands placed on SCT carriers during exercise and highlight the importance of supporting the body's cellular health to manage exercise-induced stress.
Blood rheology abnormalities and vascular cell adhesion mechanisms in sickle cell trait carriers during exercise
This scientific review explains how strenuous exercise can lead to significant changes in blood properties for individuals with Sickle Cell Trait, including an increase in red blood cell rigidity. These findings highlight the unique physiological stress that exercise places on the circulatory system of SCT carriers, underscoring the importance of nutritional support focused on maintaining healthy red blood cell function.
L-Glutamine: A Novel and Effective Therapeutic Tool for VOC Reduction in SCD
In a real-world clinical setting, this study showed that L-Glutamine therapy decreased hospitalized vaso-occlusive crises (VOC). Biologically, it improved red blood cell oxygen affinity and reduced markers of cellular aging, demonstrating its direct role in promoting more resilient and healthier red blood cells.
A Pharmacokinetic-Pharmacodynamic Analysis of L-Glutamine for the Treatment of Sickle Cell Disease
This analysis revealed that higher L-Glutamine exposure is associated with multiple positive biological effects, including improved red blood cell deformability and reduced oxidative stress (ROS) in young red blood cells. These findings help to explain the mechanisms by which L-Glutamine supports overall cellular health and function.
A Population Pharmacokinetic Analysis of L-Glutamine Exposure in Patients with Sickle Cell Disease
This pharmacokinetic study confirms that oral L-Glutamine is absorbed rapidly and effectively by the body without accumulation, supporting a reliable dosing regimen. The research also showed that its effectiveness is not significantly impacted by food, highlighting its convenience for daily use as part of any routine.
Oral L-Glutamine Therapy for Sickle Cell Anemia: I. Subjective Clinical Improvement and Favorable Change in Red Cell NAD Redox Potential
This foundational study showed that daily oral L-Glutamine therapy significantly improves the internal environment of red blood cells by increasing their NAD redox potential. This biochemical improvement helps protect red blood cells from oxidative damage and was accompanied by patient reports of increased energy levels, supporting L-Glutamine's role in promoting cellular health and vitality.